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Carcinogenesis Within a life time carcinogenicity analyze performed in B6C3F1 mice, methylphenidate prompted a rise in hepatocellular adenomas, and in males only, a rise in hepatoblastomas in a day by day dose of around 60 mg/kg/working day. This dose is close to 2 periods the MRHD of sixty mg/day provided to youngsters on mg/m2 basis.Physical Depe